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First Total Synthesis of the 2,7‐Naphthyridine Alkaloids Lophocladine A and B
Author(s) -
Lotter Matthias,
Schilling Johannes,
Reimann Eberhard,
Bracher Franz
Publication year - 2006
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200600134
Subject(s) - acetic acid , ammonium acetate , sulfuric acid , chemistry , reagent , organic chemistry , ammonium , high performance liquid chromatography
The one‐pot reaction of 4‐benzylpyridine‐3‐carbonitrile with Bredereck's reagent and subsequent treatment with either glacial acetic acid and sulfuric acid or ammonium acetate provided the new bioactive naphthyridine alkaloids lophocladine A and B, respectively.