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Synthesis and Anti‐tumor Activities of Novel Pyrazolo[1,5‐ a ]pyrimidines
Author(s) -
Li Juan,
Zhao Yan Fang,
Zhao Xiang Lin,
Yuan Xiao Ye,
Gong Ping
Publication year - 2006
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200600098
Subject(s) - chemistry , tumor cells , elemental analysis , in vitro , stereochemistry , cancer cell lines , combinatorial chemistry , mtt assay , cell culture , proton nmr , cancer , biochemistry , cancer cell , organic chemistry , cancer research , biology , genetics
A series of novel pyrazolo[1,5‐ a ]pyrimidines were designed and synthesized in order to find novel potent anti‐tumor compounds. The structures of all the compounds were confirmed by IR, 1 H‐NMR, elemental analysis, and MS. Their anti‐tumor activities against cancer cell lines were tested by the MTT method in vitro . Compound 19 displayed potent anti‐tumor activity.