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Synthesis and Evaluation of Antimicrobial Activity of Novel Hydrazino and N ‐Benzylidinehydrazino‐Substituted 4,8‐Dihydro‐1 H ,3 H ‐pyrimido[4,5‐ d ]pyrimidin‐2,7‐dithiones
Author(s) -
Sharma Pratibha,
Rane Nilesh,
Pandey Priti
Publication year - 2006
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200600067
Subject(s) - antimicrobial , gram , bacteria , pyrimidine , chemistry , stereochemistry , gram positive bacteria , antibacterial activity , in vitro , gram negative bacteria , biological activity , combinatorial chemistry , organic chemistry , biochemistry , escherichia coli , biology , genetics , gene
Abstract A number of novel pyrimido[4,5‐ d ]pyrimidine‐2,7‐dithone derivatives bearing hydrazino and N ‐benzylidinehydrazino substitution were efficiently synthesized and screened for in vitro antibacterial activities against the representative panel of three Gram‐positive and two Gram‐negative bacteria. All the synthesized compounds showed the potent inhibitory action against Gram‐positive bacteria. Particularly, N ‐benzylidinehydrazino‐substituted compounds imparted profound effect. Furthermore, the Connolly‐accessible surface area values were also calculated for the target compounds and correlated with the expressed biological activity.