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Synthesis and Aldose Reductase Inhibitory Activities of Novel O ‐Substituted Hydroxyphenylacetic Acid Derivatives
Author(s) -
Rakowitz Dietmar,
Angerer Helga,
Matuszczak Barbara
Publication year - 2006
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200600024
Subject(s) - aldose reductase , chemistry , aldehyde reductase , substituent , moiety , stereochemistry , enzyme , inhibitory postsynaptic potential , enzyme inhibitor , biochemistry , biology , neuroscience
In continuation of our work aimed towards the preparation of novel aldose reductase inhibitors, several O ‐substituted hydroxyphenylacetic acid derivatives were investigated. The highest inhibitory activity was found for compounds 7b and 7c bearing a cyclohexylmethyl substituent. This result demonstrates that within these series, this moiety is a useful surrogate for the 4‐bromo‐2‐fluorobenzyl residue which can be often found in potent aldose reductase inhibitors.