z-logo
Premium
Synthesis and Aldose Reductase Inhibitory Activities of Novel O ‐Substituted Hydroxyphenylacetic Acid Derivatives
Author(s) -
Rakowitz Dietmar,
Angerer Helga,
Matuszczak Barbara
Publication year - 2006
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200600024
Subject(s) - aldose reductase , chemistry , aldehyde reductase , substituent , moiety , stereochemistry , enzyme , inhibitory postsynaptic potential , enzyme inhibitor , biochemistry , biology , neuroscience
In continuation of our work aimed towards the preparation of novel aldose reductase inhibitors, several O ‐substituted hydroxyphenylacetic acid derivatives were investigated. The highest inhibitory activity was found for compounds 7b and 7c bearing a cyclohexylmethyl substituent. This result demonstrates that within these series, this moiety is a useful surrogate for the 4‐bromo‐2‐fluorobenzyl residue which can be often found in potent aldose reductase inhibitors.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here