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Synthesis of Furo‐salicylanilides and Their Heterocyclic Derivatives with Anticipated Molluscicidal Activity
Author(s) -
Hassan Ghaneya Sayed,
Hegazy Gehan Hegazy,
Safwat Hany Mohamed
Publication year - 2006
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200600020
Subject(s) - schistosoma mansoni , chemistry , stereochemistry , molluscicide , snail , biological activity , schistosomiasis , biology , biochemistry , helminths , ecology , zoology , in vitro
The synthesis of new furo‐salicylanilides and their heterocyclic derivatives is described. Twenty‐three compounds were screened for their molluscicidal activity against Biomphalaria alexandrina snails, the intermediate host of Schistosoma mansoni. Five of the tested compounds showed no activity, while eighteen compounds showed strong to moderate activity using bayluscide as a reference.