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Microbial Transformation of Nandrolone Decanoate by Acremonium Strictum
Author(s) -
Yazdi Mojtaba Tabatabaei,
Zanjanian Seyedeh Maryam,
Faramarzi Mohammad Ali,
Amini Mohsen,
Amani Amir,
Abdi Khosrou
Publication year - 2006
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200500235
Subject(s) - chemistry , bioconversion , biotransformation , nandrolone , hydroxylation , hydrolysis , stereochemistry , acremonium , dept , chromatography , organic chemistry , nuclear chemistry , enzyme , biochemistry , fermentation , botany , anabolism , biology
Estr‐4‐en‐3,17‐dione II , 17β‐hydroxyestr‐4‐en‐3‐one III , 15α‐hydroxyestr‐4‐en‐3,17‐dione IV , and 15α,17β‐dihydroxyestr‐4‐en‐3‐one V were produced by microbial transformation of nandrolone decanoate I in the culture of Acremonium strictum PTCC 5282. Bioconversion characteristics observed were ester hydrolysis, oxidation, and hydroxylation. Each microbial product was purified chromatographically and characterized on the basis of spectral data obtained from 1 H‐NMR, 13 C‐NMR, FT‐IR, MS, and physical constants such as melting point and optical rotation.