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A Study of Anti‐inflammatory Activity of Some Novel α‐Amino Naphthalene and β‐Amino Naphthalene Derivatives
Author(s) -
Sharma Shalabh,
Singh Tripti,
Mittal Rajan,
Saxena K. K.,
Srivastava Virendra Kishore,
Kumar Ashok
Publication year - 2006
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200500215
Subject(s) - naphthalene , naproxen , chemistry , phenylbutazone , aryl , analgesic , anti inflammatory , stereochemistry , pharmacology , organic chemistry , medicine , alkyl , alternative medicine , pathology
In the present study, some naphthalene derivatives have been synthesized by incorporating azetidinyl and thiazolidinyl moieties at its α‐ or β‐positions such as α‐(3‐chloro‐2‐oxo‐4‐substituted)aryl‐1‐azetidinyl)naphthalenes 6–10 , α‐((substituted)aryl‐4‐oxo‐1,3‐thiazolidin‐3‐yl)naphthalenes 11–15 , β‐(3‐chloro‐2‐oxo‐4‐substituted aryl‐1‐azetidinyl)naphthalenes 21–25 , and β‐(substituted aryl‐4‐oxo‐1,3‐thiazolidin‐3‐yl)naphthalenes 26–30 . These compounds have also been screened for acute toxicity and anti‐inflammatory and analgesic activities. Compounds which showed better anti‐inflammatory and analgesic activities were also examined for their ulcerogenic liability and underwent a cyclooxygenase assay. Two compounds, 12 and 28 , were found to exhibit potent anti‐inflammatory activity as compared to the standard drugs phenylbutazone and naproxen.