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Synthesis, Anticonvulsant, and Anti‐inflammatory Activities of Some New Benzofuran‐Based Heterocycles
Author(s) -
Dawood Kamal M.,
AbdelGawad Hassan,
Ellithey Mohey,
Mohamed Hanan A.,
Hegazi Bahira
Publication year - 2006
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200500176
Subject(s) - indolizine , chemistry , benzofuran , pyridinium , salt (chemistry) , aniline , pyridine , ammonium acetate , bromide , medicinal chemistry , anticonvulsant , organic chemistry , neuroscience , epilepsy , biology , high performance liquid chromatography
Treatment of 2‐bromoacetylbenzofuran ( 2 ) with pyridine afforded its corresponding pyridinium bromide 3 . The latter salt reacted with some activated alkenes and acetylenes to give the corresponding indolizine derivatives. Treatment of the salt 3 with benzylidenemalononitriles 9 afforded polysubstituted aniline derivatives, however with arylidenecyanothioacetamides 15 it gave the corresponding 4,5‐dihydrothiophenes. Bromide 3 also coupled with p ‐chlorobenzenediazonium salt followed by ammonium acetate to give the corresponding 1,2,4,5‐tetrazine derivative. The biological activity of the newly synthesized compounds was examined and some of them were found to possess anticonvulsant and anti‐inflammatory activities.