Synthesis and Potent Antimicrobial Activities of Some Novel Retinoidal Monocationic Benzimidazoles | Zendy

AtesAlagöz Zeynep | Zendy; Alp Mehmet | Zendy; Kus Canan | Zendy; Yildiz Sulhiye | Zendy; Buyukbingöl Erdem | Zendy; Göker Hakan | Zendy

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Synthesis and Potent Antimicrobial Activities of Some Novel Retinoidal Monocationic Benzimidazoles

Author(s) -

AtesAlagöz Zeynep,

Alp Mehmet,

Kus Canan,

Yildiz Sulhiye,

Buyukbingöl Erdem,

Göker Hakan

Publication year - 2006

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200500168

Subject(s) - candida albicans , antimicrobial , benzimidazole , staphylococcus aureus , corpus albicans , candida krusei , fluconazole , chemistry , antifungal , microbiology and biotechnology , pharmacology , medicine , bacteria , biology , organic chemistry , genetics

Several 2‐(5,5,8,8‐tetramethyl‐5,6,7,8‐tetrahydronaphthalen‐2‐yl)‐1 H ‐benzimidazole‐5‐carboxamidine analogues were synthesized for their antibacterial and antifungal activities against S. aureus, Methicillin ‐ resistant S. aureus (MRSA) , C. albicans , and C. krusei . MIC values of the targeted compounds 43 ‐ 58 are comparable to those of Fluconazole and Sultamicillin. The most potent compounds, 51 and 53 , showed MIC values as 0.78 and 1.56 μg/mL against S. aureus and C. albicans , respectively.

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