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Synthesis and Potent Antimicrobial Activities of Some Novel Retinoidal Monocationic Benzimidazoles
Author(s) -
AtesAlagöz Zeynep,
Alp Mehmet,
Kus Canan,
Yildiz Sulhiye,
Buyukbingöl Erdem,
Göker Hakan
Publication year - 2006
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200500168
Subject(s) - candida albicans , antimicrobial , benzimidazole , staphylococcus aureus , corpus albicans , candida krusei , fluconazole , chemistry , antifungal , microbiology and biotechnology , pharmacology , medicine , bacteria , biology , organic chemistry , genetics
Several 2‐(5,5,8,8‐tetramethyl‐5,6,7,8‐tetrahydronaphthalen‐2‐yl)‐1 H ‐benzimidazole‐5‐carboxamidine analogues were synthesized for their antibacterial and antifungal activities against S. aureus, Methicillin ‐ resistant S. aureus (MRSA) , C. albicans , and C. krusei . MIC values of the targeted compounds 43 ‐ 58 are comparable to those of Fluconazole and Sultamicillin. The most potent compounds, 51 and 53 , showed MIC values as 0.78 and 1.56 μg/mL against S. aureus and C. albicans , respectively.