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Synthesis and Biological Activity of Novel Acyclic Versions of NeplanocinA
Author(s) -
Wu Ying,
Hong Joon Hee
Publication year - 2005
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200500154
Subject(s) - chemistry , bromide , stereochemistry , biological activity , alkyl , chemical synthesis , combinatorial chemistry , organic chemistry , biochemistry , in vitro
Novel acyclic Neplanocin A analogues were designed and synthesized. The coupling of the alkyl bromide 6 with nucleosidic bases (T, U, 5‐FU, 5‐IU, C, A) and desilylation afforded a series of novel acyclic nucleosides. The synthesized compounds 13 – 18 were evaluated for their antiviral and antitumor activity.
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