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Synthesis of 5,6‐Dimethyl‐9‐methoxy‐1‐phenyl‐6 H ‐pyrido[4,3‐ b ]carbazole Derivatives and their Cytotoxic Activity
Author(s) -
JasztoldHoworko Ryszard,
Pelczynska Marzena,
Nasulewicz Anna,
Wietrzyk Joanna,
Opolski Adam
Publication year - 2005
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200500141
Subject(s) - ethylamine , chemistry , stereochemistry , carbazole , bicyclic molecule , medicinal chemistry , organic chemistry
Starting from 2‐(6‐methoxy‐1‐methyl‐9 H ‐carbazol‐2‐yl)ethylamine 7 and mixed anhydrides of 4‐nitrobenzoic acid or 4‐methoxybenzoic acid, the corresponding 5,6‐dimethyl‐9‐methoxy‐1‐(4‐substituted phenyl)‐6 H ‐pyrido[4,3‐ b ]carbazoles 11a – b , 5,6‐dimethyl‐9‐hydroxy‐1‐(4‐substituted phenyl)‐6 H ‐pyrido[4,3‐ b ]carbazoles 12a, 12c , and their quaternary salts 13a – d were obtained. The four new pyridocarbazole derivatives 12a – c and 13d satisfy the international activity criterion for synthetic compounds, namely an ID 50 value lower then 4 μg/mL in preliminary in vitro cytotoxic activity screening against the A549 cell line (non‐small cell lung cancer).