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Synthesis and Antibacterial Activity of 1β‐Methyl‐2‐[5‐(1,2‐Disubstituted Ethyl)Pyrrolidin‐3‐ylthio]Carbapenem Derivatives
Author(s) -
Ahn SooHyun,
Jeon Heechol,
Choi JoungHoon,
Baek Daejin,
Seo Seon Hee,
Cho JungHyuck,
Oh ChangHyun
Publication year - 2006
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200500139
Subject(s) - moiety , pyrrolidine , chemistry , antibacterial activity , substituent , stereochemistry , antibacterial agent , lactam , chemical synthesis , ring (chemistry) , in vitro , bacteria , organic chemistry , antibiotics , biochemistry , biology , genetics
The synthesis of a new series of 1β‐methylcarbapenems having a 5‐(1,2‐disubstituted ethyl) pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of the substituent on the pyrrolidine ring was investigated. A particular compound IIIf having a 1‐methoxyimino‐2‐carbamoylethyl substituted moiety showed the most potent antibacterial activity.