Short and Efficient Approach Towards Macrocyclic Lactones Based on a Sonogashira Reaction | Zendy

Krauss Jürgen | Zendy; Unterreitmeier Doris | Zendy; Neudert Christine | Zendy; Bracher Franz | Zendy

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Short and Efficient Approach Towards Macrocyclic Lactones Based on a Sonogashira Reaction

Author(s) -

Krauss Jürgen,

Unterreitmeier Doris,

Neudert Christine,

Bracher Franz

Publication year - 2005

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200500132

Subject(s) - sonogashira coupling , mitsunobu reaction , lactone , polyketide , combinatorial chemistry , chemistry , cancer cell lines , stereochemistry , organic chemistry , cancer cell , cancer , biology , biosynthesis , palladium , genetics , enzyme , catalysis

Polyketide‐derived macrolactones like zearalenone ( 1 ), zearalane ( 2 ) or curvularin ( 3 ) display a wide range of interesting pharmacological activities. Here, we present a short and efficient approach towards this class of natural products by a combination of the Sonogashira and Mitsunobu reactions. The resulting lactone 9 was tested against human cancer cell lines at the NCI.

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