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Short and Efficient Approach Towards Macrocyclic Lactones Based on a Sonogashira Reaction
Author(s) -
Krauss Jürgen,
Unterreitmeier Doris,
Neudert Christine,
Bracher Franz
Publication year - 2005
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200500132
Subject(s) - sonogashira coupling , mitsunobu reaction , lactone , polyketide , combinatorial chemistry , chemistry , cancer cell lines , stereochemistry , organic chemistry , cancer cell , cancer , biology , biosynthesis , palladium , genetics , enzyme , catalysis
Polyketide‐derived macrolactones like zearalenone ( 1 ), zearalane ( 2 ) or curvularin ( 3 ) display a wide range of interesting pharmacological activities. Here, we present a short and efficient approach towards this class of natural products by a combination of the Sonogashira and Mitsunobu reactions. The resulting lactone 9 was tested against human cancer cell lines at the NCI.