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4‐Chloro‐2,2‐disubstituted Chromen‐3‐carboxaldehyde: Synthesis of some Fused Polycyclic Heterocycles as Anti‐inflammatory, Analgesic, Anticonvulsant, and Antiparkinsonian Agents
Author(s) -
Hegab Mohamed I.,
Abdulla Mohamed M.
Publication year - 2006
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200500124
Subject(s) - chemistry , benztropine , thiourea , hydrazine (antidepressant) , anticonvulsant , analgesic , hydrate , ketone , reagent , carbamazepine , analgesic agents , combinatorial chemistry , pharmacology , organic chemistry , epilepsy , chromatography , medicine , neuroscience , dopamine , biology
Some new aldazino 4 , pyrazolo 5 , thieno 8 , and thiooxopyrimidino chromenes 10 were prepared via reaction of the corresponding β‐chlorocarboxaldehyde 3 with hydrazine hydrate, mercaptoacetic acid, and thiourea, respectively. Wherever, 4‐chlorochromene derivatives 2 along with 4‐chlorochromen‐3‐carboxaldehyde derivatives 3 were prepared from the corresponding ketone 1 with Vilsmeier‐Haack reagent. Some of the new products showed good anti‐inflammatory, analgesic, anticonvulsant, and antiparkinsonian activities comparable to indomethacin, diclofenace, carbamazepine, and benztropine.