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Synthesis and Biological Evaluation of Some Pyrazolinylpyridines and Pyrazolylpyridines
Author(s) -
Singh Tripti,
Sharma Shalabh,
Srivastava Virendra Kishore,
Kumar Ashok
Publication year - 2006
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200500117
Subject(s) - aminopyridines , chemistry , antifungal , aryl , elemental analysis , 2 aminopyridine , combinatorial chemistry , stereochemistry , organic chemistry , microbiology and biotechnology , biology , alkyl
Various new 2‐(1′‐acetyl‐5′‐substituted‐aryl‐2′‐pyrazolin‐3′‐yl)aminopyridines ( 3a – 3e ) and 2‐(1′‐phenyl 5′‐substituted aryl‐2′‐pyrazol‐3′‐yl)aminopyridines ( 4a – 4e ) have been derived from 2‐(substituted benzylidenylacetyl)aminopyridines ( 2a – 2e ). The structure of these compounds have been elucidated by elemental and spectral (IR, 1 H‐NMR, mass) analysis. Furthermore, above said compounds were evaluated for their insecticidal, antifungal, and antibacterial activities. Compound 4b 2‐[1′‐phenyl‐5′‐( o ‐chlorophenyl)‐2′‐pyrazol‐3′‐yl]aminopyridine, when compared for insecticidal and antifungal activities with parathion and fluconazole, respectively, was found to be the most potent one in this series. It also possessed remarkable antibacterial properties.