Synthesis of Novel Benzoic Acid Derivatives with Benzothiazolyl Subunit and Evaluation as Aldose Reductase Inhibitors | Zendy

Rakowitz Dietmar | Zendy; Hennig Barbara | Zendy; Nagano Marietta | Zendy; Steger Stefan | Zendy; Costantino Luca | Zendy; Matuszczak Barbara | Zendy

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Synthesis of Novel Benzoic Acid Derivatives with Benzothiazolyl Subunit and Evaluation as Aldose Reductase Inhibitors

Author(s) -

Rakowitz Dietmar,

Hennig Barbara,

Nagano Marietta,

Steger Stefan,

Costantino Luca,

Matuszczak Barbara

Publication year - 2005

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200500101

Subject(s) - aldose reductase , chemistry , benzoic acid , stereochemistry , enzyme , derivative (finance) , aldose , protein subunit , chemical synthesis , biochemistry , combinatorial chemistry , glycoside , in vitro , financial economics , economics , gene

Several methyl benzothiazolyloxybenzoates, S ‐isosters, and the corresponding benzoic acids were synthesized and tested as aldose reductase inhibitors (ARIs). Out of this series, the ester derivative 2a – 7 was found to exhibit the highest enzyme‐inhibitoric activity. In order to investigate this unexpected result, further modifications were carried out which allowed us to explain this finding and to open a path to a novel class of ARIs.

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