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Synthesis and In Vitro Antioxidant Activity of some New Fused Pyridine Analogs
Author(s) -
AlOmar Mohamed A.,
Youssef Khairia M.,
ElSherbeny Magda A.,
Awadalla Sit. Albanat A.,
ElSubbagh Hussein I.
Publication year - 2005
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200400953
Subject(s) - chemistry , antioxidant , in vitro , free radical scavenger , pyridine , curcumin , potency , scavenger , chemical synthesis , biological activity , stereochemistry , biochemistry , medicinal chemistry
A new series of pyrano[3,2‐ c ]pyridines, pyrazolo[4,3‐ c ]pyridines, and pyrido[4,3‐ d ]pyrimidines were synthesized and screened for their in vitro antioxidant activity. Compounds 13 , 14 , 15 , 23 , 29 , 30 , and 31 exhibited the most active oxygen free‐radical scavenger activity with percentage inhibitions of 99.4, 99.6, 99.8, 97.3, 99.0, 99.3, and 99.5 %; respectively, which is comparable to the curcumin potency. Most of the tested compounds proved to be safe towards peripheral multinuclear neutrophils (PMNs). The detailed synthesis and antioxidant activity data are reported.