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Synthesis of Some 1‐[( N, N ‐Disubstituted thiocar bamoylthio)acetyl]‐3‐(2‐thienyl)‐5‐aryl‐2‐pyrazoline Derivatives and Investigation of Their Antibacterial and Antifungal Activities
Author(s) -
TuranZitouni Gulhan,
Özdemir Ahmet,
Güven Kiymet
Publication year - 2005
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200400935
Subject(s) - micrococcus luteus , aryl , candida albicans , chemistry , pyrazoline , antibacterial activity , escherichia coli , stereochemistry , microbiology and biotechnology , organic chemistry , bacteria , biology , biochemistry , alkyl , genetics , gene
Fourteen new 1‐[( N, N ‐disubstituted thiocarbamoylthio)acetyl]‐3‐(2‐thienyl)‐5‐aryl‐2‐pyrazoline derivatives ( 7a – n ) were synthesised by reacting 1‐(chloroacetyl)‐3‐(2‐thienyl)‐5‐aryl‐2‐pyrazolines ( 5a – g ) and appropriate sodium salts of N , N ‐disubstituted dithiocarbamoic acids ( 6a , b ). The structures of the synthesised compounds were confirmed by elemental analyses, UV, IR, 1 H‐NMR and FAB + ‐MS spectral data. Their antibacterial activities against Proteus vulgaris (NRRL B‐123), Escherichia coli (NRRL B‐3704), Aeromonas hydrophila (Ankara University, Faculty of Veterinary Sciences), Salmonella typhimurium (NRRL B‐4420), Streptococcus feacalis (NRRL B‐14617), Micrococcus luteus (NRLL B‐4375) were investigated and in this investigation, a significant level of activity was illustrated. Antifungal activities of the compounds against Candida albicans and Candida globrata (isolates obtained from Osmangazi Uni. Fac. of Medicine) were found to be inactive. Compounds 7c – n were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H 37 Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. The preliminary results indicated that all of the tested compounds were inactive against the test organism.