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Synthesis and Antiparasitic Properties of New 4‐ N ‐Benzylamino‐4‐Hetarylbut‐1‐enes
Author(s) -
Kouznetsov Vladimir V.,
Castro Juliette Rivero,
Puentes Cristian Ochoa,
Stashenko Elena E.,
Martínez Jairo René,
Ochoa Carmen,
Pereira David Montero,
Ruiz Juan J. Nogal,
Portillo Carlos Fernández,
Serrano Susana Muelas,
Barrio Alicia Gómez,
Bahsas Alí,
AmaroLuis Juan
Publication year - 2005
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200400909
Subject(s) - antiparasitic , chemistry , antiparasitic agent , stereochemistry , combinatorial chemistry , pharmacology , biology , medicine , pathology
New derivatives of 4‐ N ‐benzylamino‐4‐hetarylbut‐1‐ene containing a pyridyl nucleus were synthesized from benzylamines and pyridine aldehydes. N ‐oxide derivatives were obtained from these homoallylamines. Study of the antiparasitic properties of obtained pyridine derivatives as well as of four related benzazepines previously described, was carried out using cytotoxicity assays against Trichomonas vaginalis and epimastigote form of Trypanosoma cruzi protozoa. Compounds showing activity against epimastigote T. cruzi were tested against the amastigote form; unspecific cytotoxicity against macrophages was also studied.