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Synthesis, Structure, and Cytostatic Properties of New Olivacine Derivatives
Author(s) -
JasztoldHoworko Ryszard,
Croisy Alain,
Carrez Daniele,
Jaroszewicz Iwona,
Nasulewicz Anna,
Pełczyńska Marzena,
Opolski Adam
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200400893
Subject(s) - ethylamine , cytotoxicity , chemistry , carbazole , stereochemistry , tumor cells , cell culture , l1210 cells , chemical synthesis , in vitro , organic chemistry , biochemistry , cancer research , biology , genetics
Starting from 2‐(6‐methoxy‐1‐methyl‐9 H ‐carbazol‐2‐yl)ethylamine and 6‐methylpicolinic acid, 9‐methoxy‐5‐methyl‐1‐(6‐methylpyridin‐2‐yl)‐6 H ‐pyrido[4, 3‐b]carbazole 10 and its 6‐alkylderivatives 12 – 17 were obtained. The newly obtained compounds showed significant cytostatic activity against cultured L1210 cells and high cytotoxicity towards various human tumor cell lines.