Synthesis and Potent Antimicrobial Activity of Some Novel 4‐(5, 6‐Dichloro‐1 H ‐benzimidazol‐2‐yl)‐N‐substituted Benzamides | Zendy

Özden Seçkin | Zendy; Karataş Hacer | Zendy; Yıldız Sulhiye | Zendy; Göker Hakan | Zendy

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Synthesis and Potent Antimicrobial Activity of Some Novel 4‐(5, 6‐Dichloro‐1 H ‐benzimidazol‐2‐yl)‐N‐substituted Benzamides

Author(s) -

Özden Seçkin,

Karataş Hacer,

Yıldız Sulhiye,

Göker Hakan

Publication year - 2004

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200400884

Subject(s) - enterococcus faecalis , staphylococcus aureus , antimicrobial , candida albicans , chemistry , microbiology and biotechnology , antibacterial activity , escherichia coli , corpus albicans , methicillin resistant staphylococcus aureus , bacteria , biology , biochemistry , gene , genetics

A series of 4‐(5, 6‐dichloro‐ 1H ‐benzimidazol‐2‐yl)‐N‐substituted benzamides were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus , methicillin‐resistant S. aureus (MRSA), methicillin‐resistant S. epidermis (MRSE), Enterococcus faecalis , Escherichia coli and Candida albicans . Certain compounds inhibit bacterial growth with low MIC values (μg/mL). Among them, compounds 10 and 11 exhibited the greatest antibacterial activity with MIC values of 3.12 μg/mL against S. aureus , MRSA and MRSE.

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