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Synthesis and Potent Antimicrobial Activity of Some Novel 4‐(5, 6‐Dichloro‐1 H ‐benzimidazol‐2‐yl)‐N‐substituted Benzamides
Author(s) -
Özden Seçkin,
Karataş Hacer,
Yıldız Sulhiye,
Göker Hakan
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200400884
Subject(s) - enterococcus faecalis , staphylococcus aureus , antimicrobial , candida albicans , chemistry , microbiology and biotechnology , antibacterial activity , escherichia coli , corpus albicans , methicillin resistant staphylococcus aureus , bacteria , biology , biochemistry , gene , genetics
A series of 4‐(5, 6‐dichloro‐ 1H ‐benzimidazol‐2‐yl)‐N‐substituted benzamides were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus , methicillin‐resistant S. aureus (MRSA), methicillin‐resistant S. epidermis (MRSE), Enterococcus faecalis , Escherichia coli and Candida albicans . Certain compounds inhibit bacterial growth with low MIC values (μg/mL). Among them, compounds 10 and 11 exhibited the greatest antibacterial activity with MIC values of 3.12 μg/mL against S. aureus , MRSA and MRSE.