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Synthesis and Antibacterial Evaluation of 1β‐Methyl‐2‐(5‐substituted heterocyclic carbamoyl)pyrrolidin‐3‐ylthio)carbapenem Derivatives
Author(s) -
Lee JooShin,
Choa JungHyuck,
Cho Heeyeong,
Oh ChangHyun
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200400867
Subject(s) - pyrrolidine , moiety , chemistry , antibacterial activity , chemical synthesis , lactam , antibacterial agent , stereochemistry , oxadiazole , bacteria , in vitro , combinatorial chemistry , organic chemistry , antibiotics , biochemistry , biology , genetics
>The synthesis of a new series of 1β‐methylcarbapenems having a substituted heterocyclic carbamoyl pyrrolidine moiety is described. Their in vitro antibacterial activity against both gram‐positive and gram‐negative bacteria was tested, and the effect of heterocyclic substituents on the pyrrolidine was investigated. One particular compound ( III d ) having a substituted oxadiazole moiety showed the most potent antibacterial activity.