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No Correlation between GSH Levels in Human Cancer Cell Lines and the Cell Growth Inhibitory Activities of Platinum Diamine Complexes
Author(s) -
Bracht Karin,
Neumann Christian,
Grünert Renate,
Bednarski Patrick J.
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200400620
Subject(s) - glutathione , intracellular , oxaliplatin , chemistry , platinum , in vitro , cell culture , cancer cell , carboplatin , cell growth , biochemistry , cancer , biology , enzyme , cisplatin , chemotherapy , colorectal cancer , genetics , catalysis
Increases in the intracellular levels of glutathione (GSH) in cancer cells have been implicated in the development of acquired resistance to platinum antitumor agents. On the other hand, little information is available on the relationships between the intracellular GSH levels in non‐treated cancer cells and their response to platinum complexes. The present work investigated for possible correlations between concentrations of intracellular GSH/GSSG in 14 human cancer cell lines growing in vitro and the cell growth inhibitory activities of cis platin, carboplatin, oxaliplatin, and d, l‐trans ‐1, 2‐diaminocyclohexane‐dichloroplatinum(II) (DACH‐Pt). No statistically significant correlations between GSH levels and the activities of any of the four Pt‐complexes could be found.