Premium
Synthesis of Novel Isoxazolidine Derivatives and Their Antifungal and Antibacterial Properties
Author(s) -
Kumar Kodagahally R. Ravi,
Mallesha Honnaiah,
Rangappa Kanchugarakoppal S.
Publication year - 2003
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200390015
Subject(s) - nitrone , nystatin , antifungal , cycloaddition , chemistry , biphenyl , antibacterial activity , chemical synthesis , biological activity , combinatorial chemistry , organic chemistry , stereochemistry , bacteria , microbiology and biotechnology , in vitro , biology , biochemistry , catalysis , genetics
The synthesis of some biologically interesting isoxazolidine derivatives has been accomplished by the cycloaddition reaction of C ‐(4‐biphenyl)‐ N ‐(3‐methylphenyl) nitrone and C ‐(4‐biphenyl)‐ N ‐(3‐chlorophenyl) nitrone to monosubstituted alkenes. The compounds were screened for their antibacterial and antifungal activities. Among the tested compounds 3a (ii) , 3a (vii) , 3a (viii) , 3b (iv) , 3b (vii) , and 3b (viii) showed significant antifungal activity comparable with that of the standard drug Nystatin against Botrydiplodia theobromae .
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom