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New Total Synthesis of Niphatesine C and Norniphatesine C Based on a Sonogashira Reaction
Author(s) -
Krauss Jürgen,
Bracher Franz
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300861
Subject(s) - sonogashira coupling , antimicrobial , chemistry , pyridine , bacteria , combinatorial chemistry , alkaloid , chemical synthesis , mtt assay , stereochemistry , organic chemistry , biochemistry , catalysis , in vitro , biology , palladium , genetics
The pyridine alkaloid niphatesine C and its analogue norniphatesine C were prepared in a short and efficient way starting from commercially available 3‐iodopyridine and undec‐10‐yn‐1‐ol using a Sonogashira reaction as the key step. The resulting alkylpyridines were tested for antimicrobial activity against several bacteria and fungi. The cytotoxic activities were determined in the MTT assay against HL 60 cells.