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Chiral Resolution of Some Piperidine 2, 6‐dione Drugs by High Performance Liquid Chromatography on Kromasil® CHI‐DMB Column
Author(s) -
AboulEnein Hassan Y.
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300857
Subject(s) - piperidine , chemistry , chromatography , aminoglutethimide , analyte , hexane , resolution (logic) , high performance liquid chromatography , acetonitrile , chiral column chromatography , dichloromethane , stereochemistry , organic chemistry , solvent , aromatase , medicine , cancer , artificial intelligence , breast cancer , computer science
Kromasil® CHI‐DMB chiral stationary phase (CSP) is used to resolve some piperidine‐2, 6‐diones under normal mobile phase mode. Base‐line separation was achieved using hexane and dioxane (90 : 10 v/v) for aminoglutethimide (AG), pyridoglutethimide (PG), cyclohexylaminoglutethimide (ChAG), thioglutethimide (TG), and N‐acetyl aminoglutethimide (AAG). The chromatographic parameters are reported. The chiral recognition mechanisms between the analytes and the CSP depend primarily on hydrogen bonding and/or (π‐π) interactions.