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Two New Arylnaphthalide Lignans and Antiplatelet Constituents from Justicia procumbens
Author(s) -
Weng JingRu,
Ko HorngHuey,
Yeh TingLi,
Lin HsienCheng,
Lin ChunNan
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300841
Subject(s) - chemistry , lignan , stereochemistry , ether , platelet aggregation , human plasma , spectral analysis , platelet aggregation inhibitor , traditional medicine , platelet , chromatography , organic chemistry , biochemistry , aspirin , medicine , quantum mechanics , spectroscopy , physics
Two new arylnaphthalide lignans, procumphthalide A ( 1 ) and 4‐ O ‐β‐ D ‐glucopyranosyl‐(1‴→2″)‐β‐D‐apiofuranosyldiphyllin, named procumbenoside B ( 2 ), along with cilinaphthalide B ( 3 ) and several other known compounds were isolated from the methanolic extracts of Justicia procumbens . By using NMR and other spectral methods, the structures of 1 and 2 were elucidated. Cilinaphthalide B ( 3 ), justicidin A ( 4 ), and taiwan E methyl ether ( 5 ) were shown to have an antiplatelet effect in human plateletrich plasma. In human citrated PRP, 5 showed a strong inhibitory effect on platelet aggregation induced by adrenaline in a concentration‐dependent manner, with an IC 50 value of about 27.6 μM.