Two New Arylnaphthalide Lignans and Antiplatelet Constituents from  Justicia procumbens | Zendy

Weng JingRu | Zendy; Ko HorngHuey | Zendy; Yeh TingLi | Zendy; Lin HsienCheng | Zendy; Lin ChunNan | Zendy

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Two New Arylnaphthalide Lignans and Antiplatelet Constituents from Justicia procumbens

Author(s) -

Weng JingRu,

Ko HorngHuey,

Yeh TingLi,

Lin HsienCheng,

Lin ChunNan

Publication year - 2004

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200300841

Subject(s) - chemistry , lignan , stereochemistry , ether , platelet aggregation , human plasma , spectral analysis , platelet aggregation inhibitor , traditional medicine , platelet , chromatography , organic chemistry , biochemistry , aspirin , medicine , quantum mechanics , spectroscopy , physics

Two new arylnaphthalide lignans, procumphthalide A ( 1 ) and 4‐ O ‐β‐ D ‐glucopyranosyl‐(1‴→2″)‐β‐D‐apiofuranosyldiphyllin, named procumbenoside B ( 2 ), along with cilinaphthalide B ( 3 ) and several other known compounds were isolated from the methanolic extracts of Justicia procumbens . By using NMR and other spectral methods, the structures of 1 and 2 were elucidated. Cilinaphthalide B ( 3 ), justicidin A ( 4 ), and taiwan E methyl ether ( 5 ) were shown to have an antiplatelet effect in human plateletrich plasma. In human citrated PRP, 5 showed a strong inhibitory effect on platelet aggregation induced by adrenaline in a concentration‐dependent manner, with an IC 50 value of about 27.6 μM.

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