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Antiaggregating and Antithrombotic Activities of new 1, 2, 3‐Triazolecarboxamides
Author(s) -
Cwiklicki Anke,
Rehse Klaus
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300837
Subject(s) - antithrombotic , chemistry , pharmacology , medicine
Twenty five new triazolecarboxamides related to YC‐1 were prepared and tested for their antiplatelet ( in vitro ) and antithrombotic ( in vivo ) activities. Five of them inhibited the aggregation of blood platelets (Born test, inducer collagen) with IC 50 values between 90 and 130 μM. Nine compounds exhibited significant antithrombotic properties with an inhibition of thrombus formation between 11 and 7%. Only one compound ( 8c ) showed both, in vitro and in vivo effects. In vitro , the most active compounds were 11c and 12d . They inhibit platelet aggregation with IC 50 = 90 and 95 μM. In vivo , 10a showed the strongest inhibition of thrombus formation with 11% in arterioles (5% in venules) after a single oral dose of 60 mg/kg. With serotonin as inducer both, 11c and 12d , showed lower IC 50 values namely 25 or 30 μM, respectively. Additional antiplatelet activities were found for 11c against adrenaline (IC 50 = 25 μM) and for 12d against platelet activating factor (PAF) (IC 50 = 15 μM) as inducer.