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Antioxidant Properties of Novel Benzimidazole Retinoids
Author(s) -
AtesAlagoz Zeynep,
CanEke Benay,
Coban Tulay,
Iscan Mumtaz,
Buyukbingol Erdem
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300834
Subject(s) - benzimidazole , lipid peroxidation , antioxidant , superoxide , chemistry , retinoid , moiety , in vitro , microsome , biochemistry , microsoma , pharmacology , stereochemistry , retinoic acid , biology , enzyme , organic chemistry , gene
Our approach was to examine the antioxidant activity of novel retinoid derivatives containing the benzimidazole moiety. Their in vitro effects on rat liver microasomal, NADPH‐dependent lipid peroxidation levels and superoxide anion formation were determined. Lipid peroxidation in rat liver microsomes was reduced by some of the compounds in a dose‐dependent manner.