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Recently Synthesized Class of Vinylphosphonates as Potent Matrix Metalloproteinase (MMP‐2) Inhibitors
Author(s) -
AlQuntar Abed AlAziz,
Baum Ofir,
Reich Reuven,
Srebnik Morris
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300828
Subject(s) - matrix metalloproteinase , chemistry , in vitro , combinatorial chemistry , matrix metalloproteinase inhibitor , matrix (chemical analysis) , stereochemistry , biochemistry , chromatography
An in vitro evaluation of MMP‐2 inhibitors for a series of novel vinylphosphonic acids and phosphonic esters that contain various functional groups, shows that various types exhibit excellent efficiency, and points towards potent, promising compounds. Other types displayed relatively weak activity.