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Antinociceptive Properties of Chloromaleinimides and their Sulphonyl Derivatives
Author(s) -
Walter Maria Elena,
Mora Cristiano,
Mundstock Karoline,
de Souza Mércia M.,
de Oliveira Pinheiro Andréia,
Yunes Rosendo Augusto,
Nunes Ricardo J.
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300826
Subject(s) - chemistry , aniline , nociception , aniline compounds , combinatorial chemistry , stereochemistry , pharmacology , organic chemistry , biochemistry , receptor , medicine
This report describes the synthesis of new cyclic imides obtained from the reaction between aniline and dichloromaleic anhydride with further chlorosulphonation as well as the reaction between different amines and 4‐methoxyphenol for the synthesis of imidobenzenesulphonyl derivatives. These compounds were tested as antinociceptive agents using the writhing test on mice. Some compounds, when intraperitoneally injected, proved to be potent and dose‐related antinociceptives, being several times more active than many known reference drugs.