Synthesis and Morphine Enhancement Activity of N‐[5‐(2‐phenoxyphenyl)‐1, 3, 4‐oxadiazole‐2‐yl]‐N′‐phenylurea Derivatives | Zendy

Rad Ali Almasi | Zendy; Sheikhha Majid | Zendy; Hosseini Rohollah | Zendy; Tabatabaic Sayyed Abbas | Zendy; Shafiee Abbas | Zendy

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Synthesis and Morphine Enhancement Activity of N‐[5‐(2‐phenoxyphenyl)‐1, 3, 4‐oxadiazole‐2‐yl]‐N′‐phenylurea Derivatives

Author(s) -

Rad Ali Almasi,

Sheikhha Majid,

Hosseini Rohollah,

Tabatabaic Sayyed Abbas,

Shafiee Abbas

Publication year - 2004

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200300822

Subject(s) - chemistry , oxadiazole , morphine , conformational isomerism , antagonist , stereochemistry , benzodiazepine , pharmacology , molecule , organic chemistry , biochemistry , receptor , medicine

The synthesis of N‐[5‐(2‐phenoxyphenyl)‐1, 3, 4‐oxadiazole‐2‐yl]‐N′‐phenylurea derivatives is reported. The structures of these compounds are supported by their IR, 1 H‐NMR and mass spectra. Conformational analysis and superimposition of energy minima conformers of these compounds on L‐365, 260, a known 3‐ureido‐1, 4‐benzodiazepine CCK‐B antagonist, showed that the aromatic rings fell in the same contour. Morphine analgesia enhancement evaluation of the synthesized compounds in comparison with a control group showed that compounds 8a , 8c , 8h — 8j , 8l , 8o have significant effects.

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