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Synthesis and Antihypertensive Activity of 1‐(2‐Thiazolyl)‐3, 5‐disubstituted ‐2‐Pyrazolines
Author(s) -
Bagheri Maryam,
Shekarchi Maryam,
Jorjani Masoumeh,
Ghahremani Mohammad Hossein,
Vosooghi Mohssen,
Shafiee Abbas
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300810
Subject(s) - chemistry , aryl , phenacyl bromide , ethanol , phenacyl , bromide , medicinal chemistry , spectral analysis , chemical synthesis , stereochemistry , organic chemistry , alkyl , biochemistry , physics , quantum mechanics , spectroscopy , in vitro
Several substituted 3‐aryl‐1‐(4‐aryl‐2‐thiazolyl)‐5‐(3‐pyridyl)‐2‐pyrazolines were synthesized by reacting substituted 3‐aryl‐5‐(3‐pyridyl)‐1‐thiocarbamoyl‐2‐pyrazolines with phenacyl bromide in ethanol. The structures of all compounds were confirmed by IR, 1 H‐NMR, mass spectral data and elemental analyses. The antihypertensive activity of compounds was examined by the tail‐cuff method and compared with clonidine. Compounds 24—28 showed significant antihypertensive activity.