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Synthesis and Antibacterial Activity of 1β‐Methyl‐2‐(5‐substituted oxadiazolo pyrrolidin‐3‐yl‐thio)carbapenem Derivatives
Author(s) -
Oh ChangHyun,
Dong HyunGu,
Lee JooShin,
Lee SuChul,
Hong Joon Hee,
Cho JungHyuck
Publication year - 2003
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300768
Subject(s) - moiety , oxadiazole , antibacterial activity , chemistry , thio , substituent , stereochemistry , antibacterial agent , in vitro , carbapenem , combinatorial chemistry , lactam , chemical synthesis , ring (chemistry) , bacteria , organic chemistry , antibiotics , biochemistry , biology , genetics
Synthesis of a new series of 1β‐methylcarbapenems with a substituted oxadiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of the substituent on the oxadiazole ring investigated. In particular, compounds 13a and 13c with ester and carbamoyl substituted oxadiazole moieties showed the most potent antibacterial activity.