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Synthesis of Curcumin Analogues as Potential Antioxidant, Cancer Chemopreventive Agents
Author(s) -
Youssef Khairia M.,
ElSherbeny Magda A.,
ElShafie Faiza S.,
Farag Hassan A.,
AlDeeb Omar A.,
Awadalla Sit Albanat A.
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300763
Subject(s) - chemistry , curcumin , antioxidant , cyclohexanes , cyclopentanes , free radical scavenger , stereochemistry , scavenger , biological activity , medicinal chemistry , organic chemistry , biochemistry , in vitro , catalysis
New series of 3, 5‐bis(substituted benzylidene)‐4‐piperidones, 2, 7‐bis(substituted benzylidene)cycloheptanones, 1, 5‐bis(substituted phenyl)‐1, 4‐pentadien‐3‐ones, 1, 7‐bis(substituted phenyl)‐1, 6‐heptadien‐3, 5‐diones, 1, 1‐bis(substituted cinnamoyl)‐cyclopentanes, and 1, 1‐bis(substituted cinnamoyl)cyclohexanes have been synthesized and tested for their antioxidant activity. Among the tested compounds, compounds II 4 , II 9 II 10 , II 11 , V 1 , and V 4 exhibited higher free radical scavenger activity with % inhibition values of 90.71, 91.24, 96.91, 94.26, 99.23, and 99.85%, respectively. Moreover, compound V 1 is the safest member toward peripheral multinuclear neutrophils (PMNs) with a % viability value of 91%. Detailed synthesis, spectroscopic, and biological data are reported.