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Non‐thiol Farnesyltransferase Inhibitors: FTase‐Inhibition and Cellular Activity of Benzophenone‐based Bisubstrate Analogue Farnesyltransferase Inhibitors
Author(s) -
Mitsch Andreas,
Bergemann Silke,
Gust Ronald,
Sattler Isabel,
Schlitzer Martin
Publication year - 2003
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300758
Subject(s) - farnesyltransferase , benzophenone , chemistry , farnesyl diphosphate farnesyltransferase , farnesyltransferase inhibitor , enzyme , thiol , enzyme inhibitor , biochemistry , stereochemistry , organic chemistry , prenylation
Some 5‐acylaminoacylamino‐benzophenone derivatives were designed as bisubstrate analogue farnesyltransferase inhibitors. These compounds turned out to be only weakly active against farnesyltransferase, but displayed an antiproliferative effect rendering them suitable for further development as a novel type of cytostatic agents.