Non‐thiol Farnesyltransferase Inhibitors: FTase‐Inhibition and Cellular Activity of Benzophenone‐based Bisubstrate Analogue Farnesyltransferase Inhibitors | Zendy

Mitsch Andreas | Zendy; Bergemann Silke | Zendy; Gust Ronald | Zendy; Sattler Isabel | Zendy; Schlitzer Martin | Zendy

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Non‐thiol Farnesyltransferase Inhibitors: FTase‐Inhibition and Cellular Activity of Benzophenone‐based Bisubstrate Analogue Farnesyltransferase Inhibitors

Author(s) -

Mitsch Andreas,

Bergemann Silke,

Gust Ronald,

Sattler Isabel,

Schlitzer Martin

Publication year - 2003

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200300758

Subject(s) - farnesyltransferase , benzophenone , chemistry , farnesyl diphosphate farnesyltransferase , farnesyltransferase inhibitor , enzyme , thiol , enzyme inhibitor , biochemistry , stereochemistry , organic chemistry , prenylation

Some 5‐acylaminoacylamino‐benzophenone derivatives were designed as bisubstrate analogue farnesyltransferase inhibitors. These compounds turned out to be only weakly active against farnesyltransferase, but displayed an antiproliferative effect rendering them suitable for further development as a novel type of cytostatic agents.

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