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Synthesis and Antibacterial Activity of 1β‐Methyl‐2‐(5‐substituted Imidazolino Pyrrolidin‐3‐ylthio)carbapenem Derivatives
Author(s) -
Oh ChangHyun,
Lee ChangSik,
Lee JongSun,
Cho JungHyuck
Publication year - 2003
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300756
Subject(s) - moiety , chemistry , antibacterial activity , pyrrolidine , imidazoline receptor , substituent , stereochemistry , antibacterial agent , lactam , chemical synthesis , in vitro , biological activity , bacteria , antibiotics , biochemistry , biology , pharmacology , genetics
The synthesis of a new series of 1β‐methylcarbapenems containing a substituted imidazolino pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of the substituent on the imidazoline ring was investigated. Compound 13 g which has a N‐sulfonylmethyl substituted imidazoline moiety showed the most potent antibacterial activity.