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Oxidation and Degradation Products of Papaverine, Part II[1]: Investigations on the Photochemical Degradation of Papaverine Solutions
Author(s) -
Girreser Ulrich,
Hermann Tadeusz W.,
Piotrowska Karolina
Publication year - 2003
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300751
Subject(s) - papaverine , chemistry , chloroform , degradation (telecommunications) , derivative (finance) , oxide , photochemistry , organic chemistry , medicine , telecommunications , computer science , financial economics , economics
The structure of the final degradation product formed in papaverine solutions in either water or chloroform was found to be a 2, 3, 9, 10‐tetramethoxy‐12‐oxo‐12 H ‐indolo [2, 1‐a] isoquinolinylium salt (a dibenzo [b, g] pyrrocolonium derivative). Its formation from papaverine oxidation products that is papaverinol, papaveraldine, and papaverine‐ N ‐oxide chloroformsolutions under the influence of UV light, was investigated and possible reaction pathways are discussed.