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Studies on Novel 7‐Acyl‐5‐chloro‐2‐oxo‐3 H ‐benzoxazole Derivatives as Potential Analgesic and Anti‐Inflammatory Agents
Author(s) -
Ünlü Serdar,
Baytas Sultan Nacak,
Kupeli Esra,
Yesilada Erdem
Publication year - 2003
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300748
Subject(s) - chemistry , analgesic , carrageenan , edema , pharmacology , acetic acid , moiety , vascular permeability , stereochemistry , biochemistry , medicine , pathology , psychiatry
In this study, a series of (7‐acyl‐5‐chloro‐2‐oxo‐3 H ‐benzoxazol‐3‐yl)alkanoic acid derivatives were synthesized and evaluated for their analgesic and anti‐inflammatory activities by using the p‐benzoquinone‐induced writhing test and the carrageenan hind paw edema model, respectively. Acetic acid‐induced peritoneal capillary permeability test and serotonin‐induced hind paw edema test were also employed for the most active compounds. The test results indicated that (7‐acyl‐2‐oxo‐3 H ‐benzoxazol‐3‐yl)alkanoic acids (Compounds 6 a—c , 8 a—c , 10 a—c ) were equally or more potent analgesic and anti‐inflammatory agents than aspirin and indomethacin respectively. The compounds 8a and 8c , but not 8b have the longest carbon chain on alkanoic acid moiety did not induce gastric lesion in mice.