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Synthesis and Antibacterial Activities of 4‐Pyrrolidinylthio Carbapenems: Containing Heteroaromatics as a Side Chain
Author(s) -
Cho HanWon,
Oh ChangHyun,
Lee JuShin,
Lee SooChul,
Choi JungHoon,
Cho JungHyuck
Publication year - 2003
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200300728
Subject(s) - antibacterial activity , chemistry , side chain , moiety , alkyl , stereochemistry , bacteria , antibacterial agent , in vitro , gram , chemical synthesis , combinatorial chemistry , organic chemistry , antibiotics , biochemistry , biology , genetics , polymer
The synthesis of a new series of 2‐alkyl‐4‐pyrrolidinylthio‐b‐methylcarbapenems containing the substituted heteroaromatic moieties is described. Their in vitro antibacterial activities against both gram‐positive and gram‐negative bacteria were tested. The effect of substituents on the nitrogen atoms at heteroaromatic rings was investigated. Particular compounds ( 14 b , 14 c ) containing 3‐methyl‐ and 3, 5‐dimethylpyrazolethio substituted moiety showed the most potent antibacterial activity.