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Novel 3‐Arylamino‐ and 3‐Cycloalkylamino‐5, 6‐diphenyl‐pyridazines Active as ACAT Inhibitors
Author(s) -
Toma Lucio,
Giovani Maria Paola,
Vergelli Claudia,
Dal Piaz Vittorio,
Kwon ByoungMog,
Kim YoungKook,
Gelain Arianna,
Barlocco Daniela
Publication year - 2003
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200290010
Subject(s) - pyridazine , chemistry , stereochemistry
Abstract A new series of pyridazine derivatives, structurally related to the previously reported ACAT inhibitors 3‐(cyclo)alkylamino‐5, 6‐diphenyl‐pyridazines, were synthesized and tested for their inhibitory properties. Substitution of the 3‐alkylamino chain with a phenylamino group maintains activity. In contrast, the presence of either substituents on the phenylamino group or aliphatic rings having more or less than six carbon atoms lowers it.