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Amide Derivatives of [6‐(5‐Methyl‐3‐phenylpyrazole‐1‐yl)‐3(2H)‐pyridazinone‐2‐yl]acetic Acids as Potential Analgesic and Anti‐Inflammatory Compounds
Author(s) -
Banoglu Erden,
Akoğlu Çağla,
Ünlü Serdar,
Küpeli Esra,
Yeşilada Erdem,
Şahin M. Fethi
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200200738
Subject(s) - chemistry , analgesic , anti inflammatory , pharmacology , aspirin , cyclooxygenase , carrageenan , acetic acid , in vivo , amide , stereochemistry , biochemistry , enzyme , medicine , microbiology and biotechnology , biology
In this study, amide derivatives of [6‐(5‐methyl‐3‐phenyl‐pyrazole‐1‐yl)‐3(2H)‐pyridazinone‐2‐yl]acetic acid were synthesized and tested for their in vivo analgesic and anti‐inflammatory activity by using the p ‐benzoquinone‐induced writhing test and carrageenan‐induced hind paw edema model, respectively. The analgesic and anti‐inflammatory activity of the compounds 6a , 6d , 6e , 6g , 6h and 6m were more potent than that of aspirin as an analgesic and indomethacin as an anti‐inflammatory drug, respectively. The other derivatives generally resulted in comparable activity to reference compounds. Inhibitor activity of the active compounds on cyclooxygenase isoforms was also investigated by using in vitro human whole blood assay and found that these derivatives did not exert their analgesic and anti‐inflammatory activities through COX inhibition and other mechanisms might be involved.