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Synthesis of New 2‐[1(2H)‐Phthalazinon‐2‐yl]acetamide and 3‐[1(2H)‐Phthalazinon‐2‐yl]propanamide Derivatives as Antinociceptive and Anti‐inflammatory Agents
Author(s) -
Dogruer Deniz S.,
Kupeli Esra,
Yesilada Erdem,
Sahin M. Fethi
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200200719
Subject(s) - acetamide , chemistry , nociception , anti inflammatory , chemical synthesis , stereochemistry , derivative (finance) , combinatorial chemistry , pharmacology , receptor , organic chemistry , biochemistry , medicine , in vitro , economics , financial economics
As a consequence of our ongoing studies on heterocyclic compounds for new antinociceptive and anti‐inflammatory agents bearing lactam functional group, new 2‐[1(2H)‐phthalazinon‐2‐yl]acetamide and 3‐[1(2H)‐phthalazinon‐2‐yl]propanamide derivatives have been synthesized. Among the compounds synthesized, compound 4e was found the most active derivative in terms of antinociceptive and anti‐inflammatory activities, without gastric lesions and bleeding at the given dose.