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Synthesis and Cytostatic Properties of Some 6 H ‐Indolo[2, 3‐ b ][1, 8]naphthyridine Derivatives
Author(s) -
Mastalarz Henryk,
JasztoldHoworko Ryszard,
Rulko Felicja,
Croisy Alain,
Carrez Daniele
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200200696
Subject(s) - moiety , chemistry , ring (chemistry) , stereochemistry , in vitro , combinatorial chemistry , tumor cells , organic chemistry , biochemistry , cancer research , biology
The new and efficient synthesis of the title heterocyclic ring system is described starting from suitable 2‐chloro‐1, 8‐naphthyridines. The synthesized 6 H ‐indolo[2, 3‐ b ][1, 8]naphthyridine derivatives were tested in vitro on 55 tumor cell lines for their anticancer properties. The presence of the acetylamino moiety at position 3 in the main ring system proved to be crucial for the cytostatic activity of this class of compounds.