Premium
New Derivatives of Quinazoline and 1, 2‐Dihydroquinazoline N 3 ‐Oxide with Expected Antitumor Activity
Author(s) -
MikiciukOlasik Elżbieta,
BaszczakŚwiatkiewiz Katarzyna,
Żurek Elżbieta,
Krajewska Urszula,
Różalski Marek,
Kruszyński Rafał,
Bartczak Tadeusz J.
Publication year - 2004
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200100656
Subject(s) - quinazoline , tirapazamine , chemistry , crystal structure , oxide , oxygen , stereochemistry , combinatorial chemistry , pharmacology , in vitro , cytotoxicity , organic chemistry , biochemistry , medicine
Some derivatives of quinazoline and 1, 2‐dihydroquinazoline N 3 ‐oxide were synthesised and their cytotoxic activities against human leukaemia HL‐60 cells under hypoxic and aerobic conditions were tested and compared to tirapazamine as the reference compound. Compound 8 showed 5‐fold higher toxicity under hypoxic conditions than in normal oxygen atmosphere. The structure of quinazoline derivatives was established by X‐ray crystal structure analysis.