New Derivatives of Quinazoline and 1, 2‐Dihydroquinazoline  N  3 ‐Oxide with Expected Antitumor Activity | Zendy

MikiciukOlasik Elżbieta | Zendy; BaszczakŚwiatkiewiz Katarzyna | Zendy; Żurek Elżbieta | Zendy; Krajewska Urszula | Zendy; Różalski Marek | Zendy; Kruszyński Rafał | Zendy; Bartczak Tadeusz J. | Zendy

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New Derivatives of Quinazoline and 1, 2‐Dihydroquinazoline N 3 ‐Oxide with Expected Antitumor Activity

Author(s) -

MikiciukOlasik Elżbieta,

BaszczakŚwiatkiewiz Katarzyna,

Żurek Elżbieta,

Krajewska Urszula,

Różalski Marek,

Kruszyński Rafał,

Bartczak Tadeusz J.

Publication year - 2004

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200100656

Subject(s) - quinazoline , tirapazamine , chemistry , crystal structure , oxide , oxygen , stereochemistry , combinatorial chemistry , pharmacology , in vitro , cytotoxicity , organic chemistry , biochemistry , medicine

Some derivatives of quinazoline and 1, 2‐dihydroquinazoline N 3 ‐oxide were synthesised and their cytotoxic activities against human leukaemia HL‐60 cells under hypoxic and aerobic conditions were tested and compared to tirapazamine as the reference compound. Compound 8 showed 5‐fold higher toxicity under hypoxic conditions than in normal oxygen atmosphere. The structure of quinazoline derivatives was established by X‐ray crystal structure analysis.

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