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Studies in Sugar Chemistry VII 1) . Glucuronides of Podophyllum Derivatives
Author(s) -
Nudelman Abraham,
Ruse Margaretta,
Gottlieb Hugo E.,
Fairchild Craig
Publication year - 1997
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19973300904
Subject(s) - podophyllum , chemistry , podophyllotoxin , glucuronide , in vivo , etoposide , in vitro , stereochemistry , biological activity , pharmacognosy , biochemistry , metabolism , chemotherapy , biology , genetics , microbiology and biotechnology
The antitumor activities of several glucuronide methyl esters of podophyllum derivatives were tested in vitro against two human tumor cell lines and their drug resistant sublines. The most active compound studied was methyl (4′‐carbobenzoxy‐4′‐demethylepipodophyllotoxin‐D‐glucopyranoside)uronate 19 . Compound 19 was as potent in a colon carcinoma model and was twice as potent in a lung carcinoma model as etoposide 6 . In vivo , however, in a mouse leukemia P388 model, it had only marginal activity, with a maximum T/C% value of 125 at 37 mg/kg (iv).