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Novel Carbocyclic Nucleosides Containing a Cyclopentyl Ring. Adenosine and Uridine Analogues
Author(s) -
Balo Carmen,
Fernández Franco,
Lens Evangelina,
López Carmen,
Andrei Graciela,
Snoeck Robert,
Balzarini Jan,
De Clercq Erik
Publication year - 1997
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19973300807
Subject(s) - uracil , chemistry , uridine , hypoxanthine , adenosine , stereochemistry , ring (chemistry) , biochemistry , dna , organic chemistry , rna , enzyme , gene
Abstract cis ‐3‐Aminomethylcyclopentylmethanol ( 4 ) was used as a precursor in the synthesis of carbocyclic nucleosides containing adenine, hypoxanthine, 8‐azahypoxanthine, uracil, and 5‐iodouracil bases. None of these compounds had appreciable activity against eighteen viruses in the concentration ranges tested. Two of them showed a weak cytostatic activity against three tumor lines.