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Synthesis and Bone Resorption Effect of Alkoxy‐Substituted Xanthones
Author(s) -
Pifferi Giorgio,
Re Paolo Da,
Valenti Piero,
Bisi Alessandra,
Malandrino Salvatore
Publication year - 1997
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19973300708
Subject(s) - chemistry , xanthone , bone resorption , in vivo , moiety , alkoxy group , resorption , in vitro , stereochemistry , pharmacology , drug , biochemistry , endocrinology , organic chemistry , medicine , biology , alkyl , microbiology and biotechnology
A topological modification of ipriflavone 1 , a recent antiosteoporotic drug, is described. The flavone moiety of 1 has been replaced by a xanthone one. Among the new derivatives, the 3,6‐diisopropoxyxanthone ( 2a ) has shown significant bone resorption inhibition in in vitro and in vivo tests.