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Synthesis and Action on the Central Nervous System of 3‐Substituted 2‐Phenyl‐2,3‐dihydro‐4 H ‐1,3,2‐benzoxazaphosphorin‐4‐one 2‐Oxide and 2‐Sulfide Derivatives
Author(s) -
Kostka Krzysztof,
Porada Marek,
Zyner Elzbieta,
Pakulska Wanda,
Szadowska Anna
Publication year - 1997
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19973300703
Subject(s) - sulfide , chemistry , central nervous system , oxide , medicinal chemistry , stereochemistry , organic chemistry , medicine
The synthesis of 3‐substituted 2‐phenyl‐2,3‐dihydro‐4 H ‐1,3,2‐benzoxazaphosphorin‐4‐one 2‐sulfide derivatives is described. The action of a series 2‐oxide ( 1–6 ) and 2‐sulfide ( 7–12 ) derivatives on the central nervous system has been evaluated. Compounds 1–4, 6, 7–10 exhibit neuroleptic activity. Derivatives of sulfide series act as antiserotoninergic drugs.