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Structure‐Activity Relationship Studies of CNS Agents, Part 32 [1] : Effect of Structural Modifications in 1‐Arylpiperazine Derivatives on α1‐Adrenoreceptor Affinity
Author(s) -
Mokrosz Maria J.,
Paluchowska Maria H.,
CharakchievaMinol Sijka,
Bień Anna
Publication year - 1997
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19973300605
Subject(s) - chemistry , structure–activity relationship , stereochemistry , biochemistry , in vitro
The α1‐adrenergic and 5‐HT 1A serotonergic receptor affinities of a series of 1‐arylpiperazines are presented. The role of the spacer and the influence of the terminal substituents on the α1‐adrenoreceptor affinity and the 5‐HT 1A /α1 receptor selectivity are discussed.